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The in-situ effects of mtDNA mutations in tumors In cancer, mutated mtDNA initially exerts a range of biological effects within the cell in which it originates, an influence that is described as its in-situ effect

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Each PCR product was size-selected on a 2% agarose gel, purified and eluted into 50 l of ddH 2 O using the PCR/Gel Extraction Kit (Nippon Genetics, no